Publications

Scientific articles and research reports from the HIT-GLIO consortium.

2026

1. The complement system contributes to the immunosuppressive microenvironment of uveal melanoma

   Zherka I, Kalirai H, Majorova D, Coupland S.E, Olcina MM.

   J Transl Med. 2026 Mar 9;24(1):612.

   DOI: 10.1186/s12967-026-07910-y · PubMed: 41803879

2. Systemic complement protein levels as biomarkers of chemoradiotherapy response in anal squamous cell carcinoma

   Majorova D, Samuel R, Muirhead R, Hasson A, MacLean D.J, Ismail F, Cheadle E.J, Jacobs C, Halliday D, Saunders M, Nicholson B.D, O’Neill E, Sebag-Montefiore D, Samson A, Olcina MM.

   Radiotherapy and Oncology. 2026 Jan. Volume 214, 111324.

   DOI: 10.1016/j.radonc.2025.111324 · PubMed: 41365374

3. Precision chemical engineering of dendrimers for nucleic acid delivery

   Qianqian Ni, Donald A. Tomalia, Jing Wu, Christina Galanakou, Ling Peng.

   Nat. Rev. Chem. 2026

   DOI: 10.1038/s41570-026-00855-2 · PubMed: 42458028

4. Concerted action of targeted nucleic acid therapeutics as flexible, precision and personalized cancer treatment

   Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng.

   Adv. Sci. 2026, e76840

   DOI: 10.1002/advs.76840 · PubMed: 42523056

5. Self-assembling supramolecular dendrimers for biomedical applications

   Abdechakour Elkihel, Jing Wu, Ling Peng.

   Comptes Rendus Chimie, 2026, 29, 321-347.

   DOI: 10.5802/crchim.451

6. Fluorinated amphiphilic dendrimer to improve PET imaging of cancer

   Béatrice Louis, Tom Roussel, Twiany Cruz-Dubois, Ling Ding, Zhenbin Lyu, Erik Laurini, Jessica Ou, Laure Balasse, Adrien Chabert, Vincent Nail, Ahlem Bouhlel, Françoise Dignat-George, Florence Gattacceca, Sabrina Pricl, Benjamin Guillet, Ling Peng, Philippe Garrigue.

   Small, 2026, 22, e11972.

   DOI: 10.1002/smll.202511972 · PubMed: 42084057

7. Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2

   Francesco Marrocco, Germana Cocozza, Fabrizio Antonangeli, Rizwan Khan, Giuseppe Pietropaolo, Abdechakour Elkihel, Gabriele Favaretto, Xingzi Lin, Romina Mancinelli, Ludovica Maria Busdraghi, Alice Reccagni, Gianluca Scarno, Giuseppe Sciumè, Mattia Laffranchi, Ling Peng, Valerio Iebba, Silvano Sozzani, Giuseppina D’Alessandro, Cristina Limatola.

   Gut Microbes, 2026, 18, 2623349

   DOI: 10.1080/19490976.2026.2623349 · PubMed: 41612972

2025

1. Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

   Goncalves T, Cunniffe S, Ma TS, Mattis N, Rose AW, Kent T, Mole DR, Geiller HEB, van Bijsterveldt L, Humphrey TC, Hammond EM, Gibbons RJ, Clynes D, Rose AM.

   Nucleic Acids Res. 2025 Feb 8;53(4):gkaf061.

   PubMed: 39921567

2. Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells

   Serafini M, Twigger SA, Delfas G, Mallerman M, Bailey EP, Calder EDD, Hammond EM, Conway SJ.

   J Am Chem Soc. 2025 Oct 8;147(40):36352-36364.

   DOI: 10.1021/jacs.5c10240 · PubMed: 40994151

3. UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

   Suwa T, Lee KS, Chai IJ, Clark HOL, MacLean DJ, Machado N, Rodriguez-Berriguete G, Singh L, Higgins GS, Hammond EM, Olcina MM.

   Cell Death Dis. 2025 Jul 22;16(1):547.

   DOI: 10.1038/s41419-025-07862-z · PubMed: 40695778

4. Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

   Dzwigonska M, Rosa P, Lipiec S, Obrebski T, Smyk G, Kaza B, Cyranowski S, Ellert-Miklaszewska A, Kominek A, Malik AR, Piwocka K, Mieczkowski J, Kaminska B and Leszczynska KB.

   Cell Rep. Vol 44, Issue 9, 116222 (2025).

   DOI: 10.1016/j.celrep.2025.116222 · PubMed: 40911414

5. Dendrimer engineering to overcome delivery challenges of nucleic acids

   Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng.

   Nat. Rev. Bioeng. 2025, 3, 806-807.

   DOI: 10.1038/s44222-025-00347-w

6. Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

   Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan Lucio Iovanna, Ling Peng.

   Sci. Adv. 2025, 11, eadu9948.

   DOI: 10.1126/sciadv.adu9948 · PubMed: 40561017

7. Bola-amphiphilic glycodendrimers for targeting glial cells in the brain

   Zhancun Bian, Wenzheng Zhang, Stefano Garofalo, Dinesh Dhumal, Junyue Zheng, Tom Roussel, Erik Laurini, Christina Galanakou, Clotilde Lauro, Marc Maresca, Yi Xia, Dandan Zhu, Sabrina Pricl, Xiaoxuan Liu, Cristina Limatola, Ling Peng.

   Nanoscale, 2025, 17, 27869 – 27880.

   DOI: 10.1039/D5NR03017J · PubMed: 41229216

8. Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study

   Tom Roussel, Twiany Dubois, Beatrice Louis, Erik Laurini, Ling Ding, Laure Balasse, Vincent Nail, Françoise Dignat-George, Suzanne Giorgio, Sabrina Pricl, Benjamin Guillet, Philippe Garrigue, Ling Peng.

   J. Mater. Chem. B, 2025, 13, 5041-5050.

   DOI: 10.1039/D4TB01266F · PubMed: 39699216

2024

1. Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

   Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angèle Viola, Ling Peng.

   Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2322403121.

   DOI: 10.1073/pnas.2322403121 · PubMed: 38865273